An efficient and convenient synthesis of quinazoline derivatives catalyzed by cyanuric chloride in water
Authors
Abstract:
In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new compounds characterized by IR, 1HNMR, 13CNMR, Mass spectrometry, and CHN elemental analysis. Excellent yield, clean reaction media, simple workup and easy purification are advantages of this methodology.
similar resources
A Convenient Procedure for Friedlander Synthesis of Quinoline Derivatives Catalyzed by Zirconium Dodecylphosphonate as an Efficient and Reusable Catalyst
2-Amino-substituted ketones react with α-methylene ketones under solvent-free conditions at 90 °C in thepresence of a catalytic amount of zirconium dodecylphosphonate to create the corresponding quinolinesin excellent yields. This procedure recommends numerous advantages such as easy work-up, use of mild,reusable and safe catalyst, short reaction timeand high yields. The new compounds have been...
full texta convenient procedure for friedlander synthesis of quinoline derivatives catalyzed by zirconium dodecylphosphonate as an efficient and reusable catalyst
2-amino-substituted ketones react with α-methylene ketones under solvent-free conditions at 90 °c in thepresence of a catalytic amount of zirconium dodecylphosphonate to create the corresponding quinolinesin excellent yields. this procedure recommends numerous advantages such as easy work-up, use of mild,reusable and safe catalyst, short reaction timeand high yields. the new compounds have been...
full textMild and efficient cyanuric chloride catalyzed Pictet–Spengler reaction
A practical, mild and efficient protocol for the Pictet-Spengler reaction catalyzed by cyanuric chloride (trichloro-1,3,5-triazine, TCT) is described. The 6-endo cyclization of tryptophan/tryptamine and modified Pictet-Spengler substrates with both electron-withdrawing and electron-donating aldehydes was carried out by using a catalytic amount of TCT (10 mol %) in DMSO under a nitrogen atmosphe...
full textAn efficient synthesis of α,α'-benzylidene bis(4-hydroxycoumarin) derivatives catalyzed by Tl2O3 nanoparticles
In this work, we attempted to synthesize thallium (III) oxide nano structures by direct thermal decomposition using thallium I phenylsuccinic acid coordination polymer [Tl(PsucH)]n as a precursor. Also, Tl2O3 nanoparticles have been characterized by scanning electron microscopy (SEM), X-Ray powder diffraction (XRD) and IR spectroscopy and then we report a simple and efficient method for the syn...
full textAn efficient synthesis of α,α'-benzylidene bis(4-hydroxycoumarin) derivatives catalyzed by Tl2O3 nanoparticles
In this work, we attempted to synthesize thallium (III) oxide nano structures by direct thermal decomposition using thallium I phenylsuccinic acid coordination polymer [Tl(PsucH)]n as a precursor. Also, Tl2O3 nanoparticles have been characterized by scanning electron microscopy (SEM), X-Ray powder diffraction (XRD) and IR spectroscopy and then we report a simple and efficient method for the syn...
full textMy Resources
Journal title
volume 6 issue 4
pages 363- 368
publication date 2016-09-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023